| 1813 |
Dr. Eli Ives presents the country's first pediatric course at Yale Medical College |
| 1826 |
General Hospital Society of Connecticut is established; Connecticut's first and the nation's fourth voluntary hospital |
| 1833 |
First permanent hospital building opens |
| 1862 |
U.S. Government leases hospital during the Civil War, renaming it Knight U.S. Army General Hospital |
| 1871 |
New Haven Dispensary opens as city's first outpatient clinic |
| 1873 |
New Haven Hospital opens the Connecticut Training School, one of the nation's first three nursing schools |
| 1884 |
Name of State Hospital changes to New Haven Hospital |
| 1896 |
Grace School of Nursing founded |
| 1896 |
Arthur Wright produces first X-ray in the U.S. at Yale University |
| 1913 |
First formal agreement with Yale School of Medicine |
| 1933 |
Established one of the first organized hospital volunteer departments in the country |
| 1942 |
First successful clinical use of penicillin in U.S |
| 1942 |
First use of chemotherapy as a cancer treatment in the U.S. |
| 1945 |
Grace Hospital merges with New Haven Hospital to form Grace-New Haven Hospital |
| 1946 |
First U.S. hospital to allow healthy newborns to stay in rooms with mothers |
| 1947 |
Opens the rheumatic fever-cardiac clinic, one of the nation's first regional children's heart centers |
| 1949 |
Developed first artificial heart pump in the U.S. |
| 1949 |
First U.S. hospital to introduce natural childbirth as a general service for all obstetrical patients |
| 1952 |
First cornea transplant in Connecticut |
| 1954 |
First high energy radiation treatment unit in Connecticut |
| 1956 |
First open heart surgery in Connecticut |
| 1957 |
First hospital to use fetal heart monitoring |
| 1957 |
First peritoneal dialysis in Connecticut |
| 1958 |
First hemodialysis in Connecticut |
| 1958 |
First kidney biopsy in Connecticut |
| 1959 |
Discovery of melatonin |
| 1960 |
World's first intensive care unit for newborns |
| 1963 |
First linear accelerator for cancer treatment in Connecticut |
| 1965 |
Grace-New Haven Hospital becomes Yale-New Haven Hospital |
| 1966 |
Phrenic nerve pacemaker allows quadriplegics to breathe without a respirator |
| 1967 |
First kidney transplant in Connecticut |
| 1972 |
First hospital-based newborn screening program for sickle cell anemia in the U.S. |
| 1975 |
Lyme disease identified and named |
| 1976 |
First in Connecticut to treat cancer with photons and electrons |
| 1979 |
First insulin infusion pump for diabetes |
| 1982 |
First AIDS clinic in Connecticut |
| 1983 |
First liver transplant in Connecticut |
| 1983 |
First in vitro fertilization birth in New England |
| 1984 |
First heart transplant in Connecticut |
| 1984 |
First skin bank in New England |
| 1985 |
First fetal cardiovascular center in the U.S. |
| 1985 |
First hospital-based inpatient child psychiatric unit in Connecticut |
| 1987 |
First use of photopheresis in Connecticut |
| 1988 |
First bone marrow transplant in Connecticut |
| 1988 |
First heart-lung transplant in Connecticut |
| 1989 |
First pancreas transplant in Connecticut |
| 1990 |
First single lung transplant in Connecticut |
| 1991 |
First in Connecticut to use Extracorporeal Membrane Oxygenation (ECMO) infant life support system |
| 1992 |
First heart transplant from an unmatched donor in Connecticut |
| 1993 |
First in Connecticut to use non-invasive stereotactic breast biopsy |
| 1993 |
Yale-New Haven Children's Hospital becomes first full-service children's hospital in Connecticut |
| 1997 |
First in Connecticut to use inhaled nitric oxide to treat infants with pulmonary hypertension |
| 1997 |
First documented heart transplants of adult identical twins, one in 1992, second in 1997 |
| 1998 |
First patient in New England discharged with a left ventricular assist device |
| 2003 |
First in New England to transplant a Jarvik2000 ventricular assist device into a failing heart |
| 2007 |
First in Connecticut to perform split liver transplants (in which one donated liver is transplanted into two patients); and living donor liver transplants (in which a portion of a donor's healthy liver is transplanted into another patient) |
| 2008 |
First in Connecticut to perform an "invisible incision" appendectomy, know as "Natural Orifice Transluminal Endoscopic Surgery (NOTES)," in which surgery is performed through the body's natural openings |