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(203) 688-4242

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(203) 688-4177

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(203) 688-2222

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(203) 688-3333

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(203) 688-2221

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(203) 688-3331

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Yale-New Haven Hospital
20 York Street
New Haven, CT
06510-3202

Prostate cancer

Diagnosing prostate cancer

The PSA test
The PSA (prostate specific antigen) test is a valuable diagnostic tool for detecting prostate cancer. The test detects changes in the prostate even before they can be felt by digital rectal examination. That's good news, because when detected early, prostate cancer is very treatable. You can have this test done in your physician's office. If you need a physician, call (203) 688-2000 or try Yale-New Haven Health Physician Referral Online.

The PSA test measures a protein made by prostate cells. When cancer is present, the prostate cells produce more of this protein. Results under 4 ng/mL are usually considered normal, especially if the man has a normal digital rectal exam. But as many as a quarter of men with a test result of below 4 may go on to develop prostate cancer, so it's important to have the test repeated regularly.

Results of 4-10 are considered borderline. If the digital rectal exam is normal, your physician may order a new percent-free PSA measurement. Men with results over 10 are advised to have a biopsy to rule out cancer.

Digital rectal exam
Most prostate cancers form in the back part of the prostate gland and can be felt during a digital rectal exam (DRE). While not as accurate as the PSA test, the exam is still useful in feeling tumors that may be growing. If you are 40 or older, you should have this exam done every year by a skilled practitioner who has experience in detecting prostate cancer.

TRUS (Trans Rectal Ultrasound)
If further tests are needed, your physician may perform a transrectal ultrasound. Ultrasound uses high-frequency sound waves from a probe placed in the rectum to make an image of the prostate gland on a video screen. The test is relatively painless and quick. This test is used in conjuction with needle biopsy of the prostate and is very useful in helping physicians detect any abnormal growths in the prostate, even those too small to be felt by a rectal exam.

Biopsy; needle biopsy
Needle biopsy or fine needle aspiration is a quick way for physicians to take a sample of tissue from a suspicious area. Biopsies are performed in your physician's office or on an outpatient basis at the Yale Physicians Building (directions to YPB).

Using transrectal ultrasound for guidance, a physician inserts a thin needle into the suspicious area and withdraws a small sample of tissue. The sample is then analyzed under a microscope by experienced pathologists at Yale-New Haven to decide whether it is cancer. The procedure takes about 30 minutes An appointment and physician referral are required.

See also:

Questions to ask before cancer tests

Treating prostate cancer

Cancer Services home page

Online physician referral service

Last revised: May 1, 2007 (dh)


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