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Yale-New Haven Hospital, New Haven, Connecticut, USA HealthLINK: Cancer

September 9, 1999

News this month
Using ABCD to detect melanoma

A study published in a recent issue of Cancer suggests that following the ABCD system is an effective and practical way to detect melanoma, especially when darker color is used as a defining parameter. The Asymmetry, Border, Color and Dimension criteria has helped physicians as well as patients recognize early melanoma since its introduction in 1985. Melanoma, which affects some 43,000 people each year, has been increasing about 4 percent a year since the 1970s.

The researchers evaluated the effectiveness of the ABCD system against a pathological diagnosis of melanoma in 186 patients with 195 lesions. Few studies have been done before on the effectiveness of the ABCD criteria. Because melanoma can be diagnosed very early in development, and because early diagnosis results in improved survival, primary care physicians and specialists more and more are relying on the ABCD system and learning to recognize earlier and "thinner" lesions.

The researchers, based at four institutions in Milan, Italy, treated their patients from January to December 1996. To objectively evaluate the somewhat subjective clinical characteristics of roundness, smoothness, color and size, the researchers used telespectrophotometric analysis (specialized light machines) to evaluate each nevi or mole.

Color, as measured by reflectance of light, is the most important variable in discriminating melanoma from normal moles.

They found that color, as measured by reflectance of light, was the most important variable in discriminating melanoma from normal moles. This is noteworthy because these were patients who already had moles abnormal enough to warrant surgical removal for biopsy (which confirmed these cases of melanoma). Biopsy confirmed 77 cases of suspected melanoma and 116 cases where potentially benign lesions turned out to be melanoma.

Note color darkness of moles
Prompted by their findings, the researchers suggest that the meaning of the "C" in the ABCD system be changed to color darkness from "color variegation" so patients can be on the lookout for darkened moles. "In fact, the ancient Greek root of the word melanoma means ‘black,’" the researchers reported.

Investigate suspicious moles…no matter what size
The authors cautioned against using the current standard for mole size (greater than 6 mm — about the size of a pencil eraser) to decide whether a suspicious mole warrants further investigation. Not testing small moles could force cases of melanoma to be missed. As the researchers stated, "at some point all melanomas are smaller in diameter than this (6 mm) during their early clinical life."

Watch for change
In addition, the authors suggested people should be told to watch for a change in the size of an existing lesion, or the development of a new one. Investigating new or expanding lesions would help physicians make an early diagnosis of a rare type of melanoma that presents as a light-colored or flat lesion.


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Adina Chelouche, M.D.

The importance of ABCD

In my practice, I find the ABCD system is an excellent way to begin educating my patients about skin cancer. It’s not foolproof, but it’s easy to remember and a good jumping off point that helps people become more aware of skin cancer.

"Dark color is often a tip-off for me…."

It was very interesting to read in this new study that dark color was an important characteristic in distinguishing melanoma from ordinary, noncancerous moles. This validates what I have found to be true in my own practice. Dark color is often a tip-off for me when investigating a lesion that turns out to be an atypical nevi or early melanoma.

Examine yourself
It’s important for people to perform a skin exam every few months or so, using mirrors or another person to check areas you can’t see. Doing it too often, however, may make it difficult to notice changes in your skin. Sometimes, when my patients feel overwhelmed by trying to examine every little freckle, I tell them to look at their leg, or their arm, and look for moles that really stand out because of their dark color or increase in size.

This study also agrees with past studies that the size of a lesion or mole is the weakest criteria. I tell my patients to have any and all suspicious moles or spots checked as soon as possible, no matter what size they are. When it comes to melanoma, the earlier a diagnosis is made, the better.

"Have any and all suspicious moles or spots checked as soon as possible."

Look everywhere
Melanoma can occur anywhere — on the legs, arms, back, even on the soles of the feet or palms of the hand. For women, the back of the legs is a common area while with men it’s more frequently found on the upper shoulders and back. These are usually areas that have received sun exposure. It seems that people who have intermittent, intense sun exposure may be at higher risk than people who have more constant exposure. So the farmer may be at less risk than the fair-skinned person who gets burned every year on a tropical vacation.

Sometimes people ask me to remove all of the moles on their skin, but that’s not usually recommended. For one thing, that doesn’t offer guaranteed protection against melanoma, which can originate on its own, instead of at the site of a mole. We only remove moles if they look suspicious — again maybe because of color, or if the patient feels they have changed in some way. I often can remove most lesions right in my office, and the tissue is then sent off to a laboratory and analyzed to determine if cancer is present.

Skin cancer strikes all ages
Most people may think melanoma strikes only older people, but my youngest melanoma patient was a 17-year-old girl. In fact, melanoma is the most common cause of cancer death in women aged 25 to 29, and the second most common cause in women 30 to 35 years old. But by limiting sun exposure, wearing protective clothing, doing skin exams regularly and having any suspicious areas checked by a physician, we can make a real impact against this disease.


Dr. Bevilacqua is a dermatologist on the attending staff of Yale-New Haven Hospital.

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