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Yale-New Haven Hospital, New Haven, Connecticut, USA HealthLINK: Women's Health

March 15, 2002

News this month
Poll shows people with diabetes unaware of risk for heart disease

Even though heart disease and stroke are the leading killers of people with diabetes, more than two-thirds of people suffering from this disease are not aware of their heightened risk of developing cardiovascular disease, according to a recent poll. The poll, which was commissioned by the American Diabetes Association (ADA) and American College of Cardiology (ACC), surveyed 2,008 individuals between August and October 2001.

Heart disease and stroke are the leading killers of people with diabetes.

“More than 16 million Americans have diabetes and that figure is growing at an alarming rate,” said Health and Human Services Secretary Tommy G. Thompson in announcing the survey. “Sixty-five percent of people with diabetes in the U.S. die from heart attacks or strokes. Unfortunately, most of them are not aware of the link between diabetes and heart disease and the things they can do to reduce their risk.”

Three-quarters of the patients with diabetes surveyed reported having such risk factors for heart disease as high blood pressure, high cholesterol, obesity and smoking, but they saw no connection between these problems and their diabetes.

“This research clearly illustrates the gap between perception and reality,” said Christopher D. Saudek, MD, ADA president. “The harsh reality is that if you have diabetes, you have a two to four times greater likelihood of having a heart attack than if you do not have diabetes.”

Three-quarters of diabetic patients surveyed reported having risk factors for heart disease…but saw no connection between these problems and their diabetes.

Survey findings
The survey also found:

  • 52 percent do not feel at risk for a heart problem.
  • 53 percent do not feel at risk for stroke.
  • 60 percent do not feel at risk for high blood pressure or high cholesterol.
  • 16 percent of respondents could not name one important thing they could do to reduce their risk of heart attack or stroke.

These misconceptions may be partially related to physician practices. Fifty-two percent of those surveyed, for example, said their physician had never discussed lowering blood pressure and 45 percent received no information about lowering cholesterol.

“Many knew little about the steps they can take to reduce their risks for heart disease.”

Most of those surveyed knew more about disabilities associated with their disease such as kidney damage, blindness and amputation than they did about cardiovascular complications that are often fatal. More disturbing, according to Dr. Saudek, is that many of them knew little about the steps they can take to reduce their risks for heart disease, including taking aspirin, quitting smoking and lowering their cholesterol.

Incidence of diabetes growing
While heart disease is the No. 1 killer of all Americans, patients with diabetes are at particular risk because high blood sugar damages their blood vessels. The number of people with diabetes in the United States has increased by nearly 50 percent in the past decade, with the economic toll pegged at $100 billion annually and rising. The Centers for Disease Control and Prevention project the current number of patients with diabetes will grow by 165 percent over the next 50 years.


Diabetes and Heart Disease: Yale-New Haven cardiologists and diabetologists conduct clinical trial

Participants are needed for a clinical trial that will determine the effectiveness of screening diabetic patients for “silent” heart disease, that is blockages of coronary arteries that may not be symptomatic but which may result in an eventual heart attack.

Eligible participants include those with type 2 diabetes who are free of any known heart disease and have no current cardiac symptoms. All patients will undergo a comprehensive evaluation, physical exam and EKG. Half of the participants will also undergo cardiac perfusion imaging, a safe and effective nuclear medicine study, much like a stress test, to detect silent heart problems. Participants will then be contacted by phone every six months for three years. There is no charge for any of these services. [Trial closed. No longer recruiting patients. Watch for results of the trial.]




Physician Referral Online

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Silvio E. Inzucchi, MD portrait

Manage your risk of heart disease

Although the link between diabetes and heart disease has been more widely communicated in the last five years, this survey indicates there is still a lack of understanding of the connection between the two diseases.

Almost everyone with diabetes is very aware of some of the more prominent complications of diabetes such as blindness, kidney disease and peripheral vascular problems that may result in amputations. These complications are generally restricted to patients with diabetes—unlike heart disease, which afflicts many Americans without diabetes. This may be one reason this misconception continues to exist in patients.

The fact is cardiovascular disease is the chief cause of death in between 70 and 80 percent of patients with type 2 diabetes, which is by far the more prevalent form of the disease. Diabetic patients have high levels of blood sugar in their bodies, which can damage vascular tissue and promote the atherosclerotic process. And perhaps even more important than the blood sugar level itself is a condition we call “insulin resistance syndrome” or “metabolic syndrome” that is present in the vast majority of patients with diabetes.

Metabolic syndrome
This condition is relatively common. Approximately 20 to 25 percent of Americans have a cluster of characteristics—obesity, particularly disproportionate amounts of abdominal fat; elevated blood pressure, blood sugar and triglycerides and low levels of HDL, the “good” cholesterol. Resistance to the action of the hormone insulin may be the root cause of this syndrome.

The metabolic syndrome greatly increases the risk of diabetes, heart attacks and stroke. This syndrome has led some scientists to refer to the “common soil hypothesis,” that is both diabetes and heart disease grow in the same “soil” of metabolic syndrome; hence, the strong link between the two diseases.

“Lifestyle—including overeating and a lack of exercise—may be the most important factor [in causing metabolic syndrome].”

The syndrome stimulates the diabetic process by taxing the pancreas to make more and more insulin. Once this process takes hold, it can be difficult to reverse, so preventive measures, including low-fat diet, weight loss and exercise are very important. Though experts say the syndrome may be caused by a combination of genes and lifestyle factors, lifestyle—including overeating and a lack of exercise—may be the most important factor.

What is diabetes?
Diabetes is a disease in which your body is unable to properly use and store glucose, a form of sugar. There are two major types of diabetes:

  • In type 1 (also called juvenile-onset or insulin-dependent) diabetes, your body completely stops producing insulin, a hormone that enables your body to use the glucose in foods for energy. People with type 1 diabetes must take daily insulin injections.
  • In type 2 (also called adult-onset or non insulin-dependent) diabetes, the body produces insulin, but not enough to overcome an underlying resistance to its action.

Diabetes is defined as having a fasting blood sugar level of 126 mg/dl or greater on two separate occasions. If diabetes symptoms exist and you have a random blood sugar taken at any time that is equal to or greater than 200 mg/dl, and a second test shows the same high blood sugar level, then you have diabetes.

Prediabetic state
In general, people who have a fasting blood sugar in the 110-125 mg/dl range are defined as having “impaired fasting glucose,” which can be considered a prediabetic state. A similar condition is referred to as “impaired glucose tolerance.” People with such borderline blood sugar readings can reduce their risk of type 2 diabetes by 58 percent by losing just 7 percent of their body weight and by exercising moderately for 30 minutes per day.

What can you do to reduce your risk of heart disease?
If you've been diagnosed with diabetes, there are several things you can do to reduce your risk of heart disease.

  1. Control your glucose levels. Follow your doctor's advice about diet and exercise and be aware that there are some new medications that, when used in combination with other drugs, may help you get better control of your blood sugar.
  2. Control your blood pressure and ask your physician if you should be taking an ACE inhibitor. New evidence indicates even patients with diabetes who do not have high blood pressure may reduce their risk of heart disease by taking ACE inhibitors.
  3. Seek aggressive treatment for high cholesterol. New evidence indicates even patients with diabetes who do not have high cholesterol may reduce their risk of heart disease by taking certain lipid-lowering drugs, known as “statins.”
  4. Stop smoking.
  5. Maintain a healthy weight.
  6. Exercise regularly.
  7. Talk to your doctor about taking aspirin every day.

The incidence of diabetes is approaching epidemic proportions. Both obesity and inactivity are becoming more common at younger ages, and for the first time, we are seeing type 2 diabetes in children in addition to the more highly publicized worldwide increase among people of all ages. Healthy eating habits and regular exercise can help prevent diabetes, but if you are diagnosed, learn all you can about how to minimize your risks for serious health consequences.


Dr. Inzucchi is an attending physician at Yale-New Haven Hospital, as well as the director of the Yale Diabetes Center and associate professor of medicine at the Yale University School of Medicine.


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