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Yale-New Haven Hospital, New Haven, Connecticut, USA HealthLINK: Pediatrics
March 24, 2000

News this month
Medical problems of international adoptees

Increasingly, Americans seeking to adopt a child are turning to Russia, China, Eastern Europe, Southeast Asia and South America. In 1998, about 15,000 of these orphans were adopted by U.S. citizens, a doubling over 1988 levels. Those interested in adoptions should be aware of several recent studies that have described the host of physical and emotional problems that may interfere with the adjustment of these children to their new families.

Recent studies have described a host of physical and emotional problems that may interfere with the adjustment of these children to their new families.

The majority has lived in institutions in poverty-stricken countries, where nutrition may be inadequate and hygiene poor. Some have endured emotional and physical neglect, been infected with intestinal parasites, hepatitis, tuberculosis or suffered from lead poisoning, conditions that are often not diagnosed. Compounding the problem is the fact that immigrants to the U.S. younger than 15 years old are not required to have blood tests either in their native country or when they enter the U.S., unless risk factors are identified.

Checking for lead poisoning
Lead poisoning is one example. To determine the extent of lead poisoning among these children, the federal Centers for Disease Control and Prevention (CDC) began collecting data from 12 international adoption medical specialists in the U.S. identified through the Joint Council on International Children’s Services and two collaborating medical specialists. The results were reported in the Feb. 11 issue of Morbidity and Mortality Report.

Of the 14 sites, nine centers had data on blood lead tests from children who immigrated from 1991 to 1999. The majority of the children were from Russia and China. In all, 1,760 children were tested and 111 had elevated levels of lead. The prevalence of elevated blood lead levels ranged from 1 to 13 percent among Chinese adoptees and from 1 to 5 percent among Russian adoptees. A handful of the children from China had such high levels they required chelation therapy to reduce their levels. Lead poisoning can impair intelligence and cause behavioral problems.

For some adopted children, blood lead testing occurred soon after arriving in the U.S., suggesting that exposure occurred before emigration. Sources of lead exposure outside the U.S. include leaded gasoline exhaust, industrial emissions, traditional medicines, some cosmetics, ceramic ware and foods. Among 223 Chinese children surveyed by one site, the prevalence of elevated lead levels was 2.3 times higher (18%) among children tested within four weeks of arrival in the United States than among children tested after four weeks (8%).

Reports of tuberculosis; other diseases
Other studies have identified the dangers of not screening for infectious diseases in these children. A study published in The New England Journal of Medicine last fall outlined how one adopted child’s tuberculosis went undiagnosed for two years until his female guardian contracted the disease. The boy, an immigrant from the Marshall Islands, had never been screened for TB. In all, 118 people he had come in contact with were given preventive treatment.

Many parents and physicians in the U.S. are not aware of the need for proper evaluation and follow-up of these children.

Educating parents and physicians
In that same issue, Dr. Laurie Miller, an adoption medicine specialist in Boston, wrote an accompanying editorial. She noted that, despite the recommendations of the American Academy of Pediatrics and other health organizations, many parents and physicians in the U.S. are not aware of the need for proper evaluation and follow-up of these children. Nor do they know about the existence of adoption medicine specialists in the U.S.

Dr. Miller outlined several assumptions that continue to plague the international adoption system, including:

  • Screening upon arrival in the U.S. is not necessary because the child was screened in his country of origin.
  • Children don’t need to be screened because they look healthy.
  • Follow-up screening is not necessary (a problem because some diseases take weeks to show up).
  • Immunizations performed in the countries of origin will adequately protect the child.


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Margaret Hostetter, M.D.

What parents should do before an international adoption

The data from adoptees in the Yale International Adoption Clinic was similar to the CDC results. Of the 93 children screened here, 22 were from China and 38 were from Russia. We saw elevated lead levels in three of the children from China and one from Russia. The CDC study once again underscores the need for careful evaluation of these children by physicians familiar with these issues.

The International Adoption Clinic
In the Yale International Adoption Clinic, we now see an average of three children every Monday morning. This correlates with the overall increase we see nationally. A typical evaluation usually takes a couple of hours. Our nurse practitioner first addresses the parents’ general questions, which may include issues surrounding diet, sleeping patterns or tantrums. Then one of the pediatric infectious disease specialists performs a complete medical examination, after which our behavioral/ developmental pediatrician provides an age-appropriate assessment of the child’s development in gross motor, fine motor and language skills. Blood tests recommended by the American Academy of Pediatrics are performed at the end of the visit. In a few days, we have the results from the lab work back and we call the parent and send a letter to the child’s regular pediatrician. The parents also get a copy of our letter.

“…half of the internationally adopted children we tested had a major medical issue at the time of their arrival.”

No X-ray vision
One of the things I emphasize to parents is that we pediatricians can’t tell the health of a child just by looking at him or her. Physicians don’t have X-ray eyes. That’s the lesson we learned in 1989 when the work we did in Minnesota showed that half of the internationally adopted children we tested had a major medical issue at the time of their arrival. You have to do the blood work to know exactly what’s going on, a point Dr. Miller makes loud and clear in her editorial.

Shift in trends
Before 1991, 70 percent of international adoptions came from Korea, where the children are raised in foster homes, not orphanages. These children tend to have better nutrition and better development. Adoptions from Romania began in 1991 and were quickly followed by the opening of programs in Russia and China. In 1991, Korea limited the number of adoptable children and now 70 percent of the children come from China and Russia, 20 percent from Korea and 10 percent from Southeast Asia and South America.

“…look for written findings that include explicit information about the head, eyes, nose, throat, chest, heart, abdomen, etc.”

Steps to take before adoption
Parents interested in international adoptions should know what to expect. A lot depends on the agency working for them.

First, the agency should supply baseline data on the child–the height, weight and head circumference at birth, as well as at regular intervals. It’s important to see the growth patterns over time.

There should also be detailed information in the child’s record about physical examinations performed. Be wary of reports that say, "Everything looks okay." Instead, look for written findings that include explicit information about the head, eyes, nose, throat, chest, heart, abdomen, etc.

Tests for certain diseases, such as hepatitis B, HIV or syphilis are not standardized and are performed inconsistently. Parents need to know that the accuracy of those tests done in other countries cannot be guaranteed. In China, Russia and Eastern Europe, adoption specialists have found that laboratory testing for hepatitis B is wrong 6 - 10 percent of the time. Parents should be sure they understand who pays for these tests. Sometimes it’s included in the agency fee, but repeat tests may be extra.

Look in the record for discussion of the child’s development, such as the age at which the child rolled from back to stomach, followed a toy with the eyes, sat alone, crawled or stood alone.

Expect a video of the child if coming from Russia or Eastern European countries, such as Lithuania or Romania, where this is a standard practice. If there is not a video available, that should raise a red flag. As a rule, agencies working in South Korea, China, Southeast Asia and South America do not provide videos.

Talk with other agencies and parents to see if the information you are getting is detailed and complete, or very scanty.

Beware of agencies that guarantee a perfectly healthy child or seem reluctant if you seek medical advice. A realistic approach to the issues of adoption is preferable to a Cinderella story. Remember, these are children who, in many cases, have spent a lot of time in orphanages. The child may even be an older child who remembers his separation from his biological parents and now has to attach again.

Unique problems
In addition to the overall guidelines, each country has its own unique issues. Children from Russia and Eastern Europe, for example, have a higher percentage of fetal alcohol syndrome. There’s a higher prevalence of hepatitis B in China, where 8 to 10 percent of women of childbearing age are infected. In Korea, watch for TB.

In Russia and in South American countries, syphilis is more common. Adoptions from South America should include DNA testing to make sure the woman who has surrendered the child is actually the child’s mother.


Dr. Hostetter is professor and chief of pediatric immunology at Yale University School of Medicine and director of the Yale Child Health Research Center.

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