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Yale-New Haven Hospital, New Haven, Connecticut, USA HealthLINK: Women's Health
March 17, 2003

News this month
New cream reduces skin damage from sun

A daily application of a new skin cream for six months may reduce the fine wrinkling and skin discoloration caused by years of sun exposure. Researchers say the cream, which contains 0.1 percent of a substance called tazarotene, reduces the effects of ultraviolet light exposure and minimizes wrinkles, discoloration and roughness. The study appeared in The Archives of Dermatology.

Daily application of a new skin cream may reduce fine wrinkling and skin discoloration caused by years of sun exposure.

Part of the Retin-A family
Tazarotene is among the vitamin A derivatives known as retinoids. It is part of the same group of compounds as the widely used Retin-A® and Renova®, both of which contain the same active ingredient, tretinoin. These prescription products are known to build collagen, regenerate the elastin that lets skin stretch and reverse abnormal pigmentation.

Much of what is known about Retin-A is based on its 30-year track record as an acne treatment. Creams and gels containing tazarotene are used to treat acne as well as some types of psoriasis. In October 2002, the FDA approved a request from the manufacturer to market the tazarotene cream, sold as Avage®, to fight wrinkles.

Initial studies of the cream indicate it could reduce signs of sun damage when used daily for 12 weeks. In this study, Tania J. Phillips, MD, of the Boston University School of Medicine studied whether using the cream longer would produce similar results.

Study results promising
More than 500 patients with sun-damaged skin applied either Avage or a placebo cream to their faces once a day for 24 weeks. After 24 weeks, all patients who remained in the study used the Avage cream for an additional 28 weeks. The average age of the participants was 56.

More patients who used the tazarotene cream experienced at least 50 % improvement in skin appearance.

After 24 weeks, researchers found significantly more patients who used the tazarotene cream experienced a more than 50 percent overall improvement in skin appearance compared to those who received the placebo. The Avage users also reported less wrinkling, mottled pigmentation and skin roughness.

Even more benefits were seen among those who used the cream for up to 52 weeks. Researchers say the improvements did not taper off by week 52, which suggests that the benefits may continue to increase over time.

Twenty of the 283 Avage-treated patients in phase one of the study dropped out due to adverse effects, including skin burning, itching, redness, dryness and irritation.










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Ronald C. Savin, MD portrait

Variety of options for sun damage

Lines, wrinkles, uneven pigmentation and age spots—these are the signs of aging on our skin and most of them are a direct result of exposure to the sun. Photoaging of the skin is a common problem. Anyone who is exposed to sun gets it; and the more sun exposure, the more damage.

“Lines, wrinkles, uneven pigmentation and age spots…are…most[ly]…a direct result of exposure to the sun.”

There are some things you can do to improve that damage, but the best thing is to prevent further damage by wearing sunscreen every day, winter and summer, with a minimum SPF of 15.

Cigarette smoking also contributes to aging effects by the biochemical changes it brings about in skin tissues. Chemicals inhaled from cigarette smoke constrict tiny blood vessels in the skin, reducing the oxygen and nutrient supply to delicate facial tissues. Blood-vessel constriction lasts at least an hour after a cigarette has been snuffed out. Over many years of smoking, the oxygen and nutrient deficiencies cause skin to wrinkle prematurely and lose elasticity. So, here’s another reason to stop smoking.

Retinoids
If you already have sun damage, there are ways you can improve how your skin looks. The results of this latest study of tazarotene cream are similar to those of other retinoids. Extensive studies have been done of Retin-A and Renova, and the results, as in this study, indicate a statistical benefit in terms of improving fine wrinkling, irregular pigmentation and coarse texture.

It is unrealistic to expect dramatic changes, however. The improvement is usually relatively subtle, but noticeable in the double-blind studies that have been conducted.

Many patients do experience some irritation, redness, dryness or flaking when beginning a regimen of retinoids. A small percentage of patients find the irritation serious enough to cause them to discontinue the products, but most find that these symptoms abate within a few weeks.

Retinoids work by sloughing off the dead outer layers of the skin, exposing the skin underneath and promoting the growth of collagen, which thickens the skin fibers that preserve moisture. By removing dead surface cells that become harder to shed as we age, and by thinning and flattening the outer layer of skin, retinoids give skin that much-valued “rosy glow.”

Other options for photoaged skin?

OTC products
Hundreds of over-the-counter (OTC) preparations are advertised as having anti-aging benefits. They vary in price from reasonable to very expensive. Many of these products may be effective moisturizers, but none has any proven benefit to sun-damaged skin.

AHAs
Also widely hyped are alpha hydroxy acids (AHAs). They’re less irritating than the retinoids, but they don’t penetrate as deeply. Be aware that it's the prescription creams that have been found effective. The small amount of AHAs in over-the-counter moisturizers and facial treatments may not make much difference to your skin.

Stronger solutions can have a significant impact, but they must be administered by a physician. At concentrations of 30 percent and higher, glycolic acid is known to increase collagen production and skin elasticity and to thicken the epidermis.

Laser skin resurfacing
New-age lasers burn off top skin layers in lined areas and injure the dermis so collagen will reform. Healing takes a week or more; redness persists for weeks to months. The newer “laser facial” or “photo-facial” procedures bypass the skin surface and go straight to the dermis, where they’re said to encourage collagen production, but this can take months. Laser skin resurfacing is expensive and long-term studies on the outcomes of laser work are not available.

Microdermabrasion
This popular procedure is essentially a mild sanding of the skin’s surface, a kind of mechanical acid peel with a bit of vacuum effect. Some patients report good results after multiple treatments. It has been shown to be effective for post-acne scarring.

Injected fillers
These substances, most often collagen or fat, are injected directly into the wrinkle to plump up creased and sunken areas of the face. The effect is temporary, and some people can have allergic reactions.

Chemical peels
Peels tighten the skin by promoting growth of collagen and elastin; they also remove fine lines and wrinkles. The stronger the acid used, the more dramatic the improvement. Mild peels cause the outer layer of skin to slough off in two to three days. Medium-strength peels create enough crusting, scaling and oozing to remove deeper scars and wrinkles, but they’ll keep you out of circulation for a week to 10 days. Deep phenol peels can eliminate major sun damage and wrinkles, but the patient is out of commission for a couple of weeks, and the resulting redness takes months to fade.

If you’re considering any of these treatments, be sure to consult with a medical specialist and fully understand the risks as well the benefits you may realistically expect.


Dr. Savin is a dermatologist and founder of the Savin Center in New Haven. He is an attending physician at Yale-New Haven Hospital and a clinical professor of dermatology at the Yale University School of Medicine.


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