
I-91 traveling south Exit 1 to Route 34(Downtown New Haven). Route 34 becomes N. Frontage Road. Turn left onto Park Street. Go through the light at S. Frontage Road. Smilow Cancer Hospital is on the left.
Route 1 (Boston Post Road) traveling east Turn left at the intersection with Ella T. Grasso Boulevard (Route 10), and right at the next light onto Legion Avenue, also known as South Frontage Road. After 1 mile, turn right onto Park Street. Smilow Cancer Hospital is on the left.
Wilbur Cross Parkway (Route 15) traveling north Exit 57 to Route 34 east into New Haven. Proceed on Route 34, also known as Derby Avenue, for about 5 miles. Turn right (south) at the intersection with Ella T. Grasso Boulevard (Route 10), and left at second light onto Legion Avenue, also known as South Frontage Road. After 1 mile, turn right onto Park Street. Smilow Cancer Hospital is on the left.

Route B - West Haven to Yale-New Haven Hospital
Route O - Sylvan Ave./Route 1, Milford to Yale-New Haven Hospital
Downtown Commuter Connection/Shore Line East
(shuttle from Union Station to York & Cedar)