Aortic Aneurysms An aortic aneurysm is an abnormal bulge in the wall of the aorta, the body's largest artery. Aneurysms often cause no symptoms, but they can be life-threatening if they get too large and rupture or burst. The Aortic Institute at Yale New Haven Hospital is a multidisciplinary specialty center dedicated to the care of patients with medical and surgical conditions that affect the aorta. Led by John Elefteriades, MD, and Sandip Mukherjee, MD, our team of cardiothoracic surgeons, cardiologists, vascular surgeons, interventional radiologists and diagnostic radiologists monitor aneurysm activity, screen family members and perform surgery and stent grafting for large aneurysms. Some of our clinical research findings have been groundbreaking as in the study of how ascending aortic aneurysms can prevent arteriosclerosis and in the connection between weightlifting and aortic dissection.