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Overview

Medical oncology is a specialized field of medicine that focuses on the diagnosis, treatment, and prevention of cancer. At Smilow, patients meet with a physician, known as a medical oncologist, who specializes in treating many different types of cancer. They use a variety of treatments to manage cancer and improve patients' quality of life using therapies such as chemotherapy, hormone therapy, targeted therapy and immunotherapy. They often serve as the primary healthcare provider for cancer patients and may coordinate treatment with other oncology specialists such as surgical or radiation oncologists.

Throughout treatment, patients receive personalized support from an intake specialist and a nurse coordinator, who will offer clear communication and comprehensive assistance every step of the way. Understanding that cancer affects more than just your physical health, we extend our support to include your psychological well-being, offering compassion and understanding to help you navigate the emotional challenges of your diagnosis.

In partnership with Yale Cancer Center, our physicians, scientists, and staff are committed to advancing the science and practice of medical oncology by understanding the molecular basis of the disease and translating these advances to patient care through clinical trials. Clinical trials are an essential part in the evolution in cancer care to help patients with better outcomes.

Clinical Trials

Clinical trials are research studies that test how well new medical approaches work in people. Each study answers scientific questions and tries to find better ways to prevent, screen for, diagnose, or treat a disease. People who take part in cancer clinical trials have an opportunity to contribute to knowledge of, and progress against, cancer. They also receive up-to-date care from experts.

Learn more about Cancer Clinical Trials

What is Chemotherapy?

Chemotherapy, often called chemo, is a type of cancer treatment that uses medication to kill or slow the growth of cancer cells. Chemotherapy travels throughout the body’s bloodstream and is primarily used to treat cancer, but it can also be used to shrink tumors, relieve symptoms, and prevent cancer from recurring. Chemotherapy treatments are specifically tailored to each patient’s unique cancer and s often used in combination with other treatments like surgery, radiation or targeted therapy. Side effects may vary in each patient.

How does chemotherapy work?

Chemotherapy works by interfering with the growth and division of cells, particularly fast-growing cells like cancer cells. While chemotherapy targets cancer cells, it can also affect healthy, fast-growing cells, leading to side effects.

What are the different types of chemotherapy?

  • Adjuvant chemotherapy: Given after surgery or radiation to kill remaining cancer cells.
  • Curative chemotherapy: Used as the primary treatment to eliminate all cancerous cells.
  • Neoadjuvant chemotherapy: Given before surgery or radiation to shrink tumors.
  • Palliative chemotherapy: Used to relieve symptoms and prolong life, but cancer may eventually become fatal.

How is chemotherapy administered?

  • Injection: Into a muscle, under the skin, or directly into the spinal fluid.
  • Intravenous (IV) infusion: Through a needle or catheter inserted into a vein.
  • Oral: As pills or capsules.
  • Topical: Applied to the skin.

What are the side effects of chemotherapy?

  • Diarrhea or constipation
  • Fatigue
  • Hair loss
  • Increased risk of infection (due to decreased white blood cell count)
  • Loss of appetite
  • Mouth sores
  • Nausea and vomiting

What is Hormone Therapy?

Hormone therapy for cancer, also known as hormonal therapy or endocrine therapy, is a cancer treatment that either lowers the amount of hormones in the body or blocks hormones from attaching to cancer cells. This approach is used because certain cancers, like some breast and prostate cancers, rely on hormones to grow. By interfering with hormone production or action, hormone therapy can slow down or stop the growth of these hormone-sensitive cancers.

How does hormone therapy work?

Hormone therapy works by targeting specific hormones that promote cancer cell growth. An example is that some breast cancers rely on estrogen to grow, while prostate cancers rely on androgens like testosterone. Hormone therapy can be used to reduce hormone production or block hormones from attaching to cancer cells. It may be used as a primary treatment for hormone sensitive cancers, before or after surgery, or in combination with other therapies like chemotherapy or radiation.

How are hormone therapies administered?

  • Injection: Into a muscle, under the skin
  • Oral: As pills or capsules.
  • Surgery: In certain cases, surgery may be used to remove organs that produce hormones.

What are the side effects of hormone therapy?

  • Blood clots
  • Bone thinning (osteoporosis)
  • Breast tenderness or swelling
  • Changes in vision
  • Diarrhea
  • Fatigue
  • Heart problems
  • Hot flashes
  • Increased risk of other cancers
  • Mood changes
  • Muscle and joint pain
  • Nausea and vomiting
  • Sexual dysfunction
  • Weight gain

What is Targeted Therapy?

Targeted therapy is a type of cancer treatment that uses medication to specifically target molecules inside or on the surface of cancer cells, hindering their growth and survival while minimizing harm to healthy cells. It's a form of precision medicine, where treatment is tailored to the unique characteristics of an individual's cancer.

How does targeted therapy work?

Targeted therapy in cancer treatment works by targeting specific molecules. The medication focuses on molecules that play a crucial role in cancer cell growth, division, and spread. Targeted therapy Interfering with cancer cell processes. These therapies can block signals that tell cancer cells to grow and divide, stop tumors from developing new blood vessels (which they need to grow), or deliver toxins directly to cancer cells. Also, targeted therapy helps by minimizing damage to healthy cells by targeting specific molecules, which aim to avoid the widespread damage to healthy cells that can occur with treatments like chemotherapy.

How are targeted therapies administered?

  • Injection: Into a muscle, under the skin
  • Oral: As pills or capsules.
  • Surgery: In certain cases, surgery may be used to remove organs that produce hormones.

What are the side effects of targeted therapies?

  • Blood Clotting Problems
  • Cardiovascular Issues
  • Fatigue
  • Gastrointestinal Issues
  • Liver Problems
  • Skin Problems

What is immunotherapy?

Immunotherapy for cancer is a type of treatment that uses the body's own immune system to fight cancer cells. It works by either boosting the immune system's ability to attack cancer cells or by modifying cancer cells to make them more sensitive to immune attack. Immunotherapy differs from traditional treatments like chemotherapy and radiation, which directly target cancer cells.

How does immunotherapy work?

  • Boosting the immune system: Aims to generally enhance the immune system's overall ability to fight cancer.
  • Cellular therapies: Modifies a patient's own immune cells to recognize and destroy cancer cells.
  • Checkpoint inhibitors: Blocks proteins that act as "brakes" on the immune system, allowing it to attack cancer cells more effectively.
  • Targeting cancer cells: Helps the immune system recognize and attack specific cancer cells.

How are immunotherapies administered?

  • Injection into Body Cavity: In some cases, immunotherapy may be administered directly into a body cavity where the tumor is located.
  • Injection: Into a muscle, under the skin, or directly into the spinal fluid.
  • Intravenous (IV) infusion: Through a needle or catheter inserted into a vein.
  • Intravesical Therapy: In bladder cancer, immunotherapy drugs might be instilled directly into the bladder using a catheter.
  • Oral: As pills or capsules.
  • Topical: Applied to the skin.

What are the side effects of immunotherapies therapies?

  • Digestive Issues
  • Fatigue
  • Flu-like Symptoms
  • Injection Site Reactions
  • Skin Reactions
Yale School of Medicine

Yale New Haven Health is proud to be affiliated with the prestigious Yale University and its highly ranked Yale School of Medicine.