Popular Locations
- Smilow Cancer Hospital
- Smilow Cancer Hospital Care Center - North Haven
- Smilow Cancer Hospital Care Center - Park Avenue Medical Center
The Stem Cell Transplant and Cellular Therapy Program at Smilow Cancer Hospital offers advanced treatments including bone marrow transplants, Chimeric Antigen Receptor T-cell (CAR-T) Therapy, Tumor Infiltrating Lymphocytes (TIL), and cell-based Gene Therapies. We also provide access to innovative cellular therapy clinical trials for a wide range of cancers and select non-cancerous diseases
Our multidisciplinary team of experts delivers comprehensive, patient-centered care for adults. Pediatric patients are cared for at Yale New Haven Children’s Hospital. Through our affiliation with Yale Cancer Center – Connecticut’s only National Cancer Institute-Designated Comprehensive Cancer Center – we offer access to leading-edge therapies and clinical research.
Cellular therapies harness the body’s immune system to treat diseases, including certain cancers. These therapies involve collecting specific cells from either blood, bone marrow, or tumor tissue, which are then modified or expanded to target and eliminate the disease.
At Smilow Cancer Hospital, we are committed to delivering the most advanced cellular therapies and stem cell transplantation treatments available today. As part of one of the nation’s leading cancer centers, our program combines world-class clinical expertise, groundbreaking research, and compassionate, patient-centered care to achieve the best possible outcomes for patients with blood cancers, bone marrow disorders, immune diseases, and other serious conditions.
Through our affiliation with Yale Cancer Center—designated a Comprehensive Cancer Center by the National Cancer Institute since 1974—we provide patients access to one of the nation’s leading cancer programs. This prestigious designation is awarded to only a select group of centers recognized for excellence in cancer research, treatment, prevention, and education. As a result, our patients benefit from innovative therapies, multidisciplinary expertise, and access to cutting-edge clinical trials that may not be available elsewhere.
Our Stem Cell Transplant and Cellular Therapy Program is accredited by the Foundation for the Accreditation of Cellular Therapy (FACT), reflecting our commitment to the highest standards across every aspect of care, from cell collection and laboratory processing to treatment, recovery, and long-term follow-up.
What sets Smilow Cancer Hospital apart is our ability to bring scientific discovery into our clinical care. Our physicians and researchers are actively developing and studying the next generation of cellular therapies, giving patients access to novel treatments through clinical trials while delivering exceptional care using today's most advanced standards. As a leading academic medical center, we continually advance the field through clinical research, novel transplant approaches, and innovative strategies to reduce complications while improving cure rates.
CAR T-cell therapy uses specially engineered immune cells called T-cells to find and kill cancer cells. The patient's own T-cells (or, less commonly, donor T-cells) are collected, genetically modified in the laboratory to express a Chimeric Antigen Receptor (CAR) which helps them to recognize a specific protein on the cancer cells, and then returned to the patient to attack the cancer cells throughout the body.
Cell-based gene therapy represents a new era of personalized medicine, offering the potential for life-changing and, in some cases, curative treatment for certain inherited blood disorders. These therapies are designed for people whose blood cells do not work properly due to an inherited genetic condition. Instead of using cells from a donor, we collect the patient's own blood-forming stem cells and send them to a specialized laboratory. There, the cells are genetically modified to correct or overcome the genetic problem causing the disease. The corrected cells are then returned to the patient, where they can grow and produce healthy blood cells that function normally. This approach may provide long-term disease control and can reduce or eliminate the need for a stem cell transplant from a donor, which carries additional risks and side effects.
Stem cell and bone marrow transplantation is a potentially curative treatment for many blood cancers, bone marrow disorders, and other serious hematologic diseases. By replacing diseased or damaged blood-forming cells with healthy stem cells, transplantation can restore normal blood production and, in some cases, provide a cure.
Tumor-Infiltrating Lymphocyte (TIL) therapy is a personalized cellular immunotherapy that is currently FDA-approved for certain patients with advanced melanoma whose disease has progressed despite prior treatment.
When Marc St. Martin was diagnosed with cutaneous T-cell lymphoma (CTCL) in 2007, he had no way of knowing the impact it would have throughout his family. Over the course of five years, Marc underwent treatment with spot radiation therapy, total skin electron beam therapy, and chemotherapy, all in the hopes of achieving a durable remission.
Read MoreYale New Haven Health is proud to be affiliated with the prestigious Yale University and its highly ranked Yale School of Medicine.